239000002202 Polyethylene glycol Substances 0.000 description 86.DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound S()(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 88.229920001223 polyethylene glycol Polymers 0.000 description 90.LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 98.150000003904 phospholipids Chemical class 0.000 abstract description 22.239000006184 cosolvent Substances 0.000 abstract description 32.239000004094 surface-active agent Substances 0.000 abstract description 44.229920000858 Cyclodextrin Polymers 0.000 abstract description 50.235000019438 castor oil Nutrition 0.000 claims description 8.239000004359 castor oil Substances 0.000 claims description 8.235000019345 sodium thiosulphate Nutrition 0.000 claims description 18.S()(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 18 AKHNMLFCWUSKQB-UHFFFAOYSA-L Sodium thiosulphate Chemical compound.231100000566 intoxication Toxicity 0.000 claims description 22.231100000601 Intoxication Toxicity 0.000 claims description 22.239000002736 nonionic surfactant Substances 0.000 claims description 24.150000001875 compounds Chemical class 0.000 claims description 38.239000008194 pharmaceutical composition Substances 0.000 claims description 44.235000010288 sodium nitrite Nutrition 0.000 claims description 58.N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims description 116 LPXPTNMVRIOKMN-UHFFFAOYSA-M Sodium nitrite Chemical compound.239000003125 aqueous solvent Substances 0.000 claims abstract description 24.XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 172.239000000729 antidote Substances 0.000 title abstract description 56.230000002605 anti-dotal Effects 0.000 title abstract description 68.239000000203 mixture Substances 0.000 title abstract description 168. XFXPMWWXUTWYJX-UHFFFAOYSA-N cyanide Chemical compound N# XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 title claims abstract description 140.YWHLKYXPLRWGSE-UHFFFAOYSA-N Dimethyl trisulfide Chemical compound CSSSC YWHLKYXPLRWGSE-UHFFFAOYSA-N 0.000 title claims abstract description 932.Assignors: SAM HOUSTON STATE UNIVERSITY Status Active legal-status Critical Current Anticipated expiration legal-status Critical Links Assignors: KOVACS, KRISTOF, PETRIKOVICS, ILONA Application granted granted Critical Publication of US9456996B2 publication Critical patent/US9456996B2/en Assigned to US ARMY, SECRETARY OF THE ARMY reassignment US ARMY, SECRETARY OF THE ARMY CONFIRMATORY LICENSE (SEE DOCUMENT FOR DETAILS). Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority claimed from US201461978504P external-priority Application filed by Sam Houston State University filed Critical Sam Houston State University Priority to US14/685,014 priority Critical patent/US9456996B2/en Publication of US20150297535A1 publication Critical patent/US20150297535A1/en Assigned to SAM HOUSTON STATE UNIVERSITY reassignment SAM HOUSTON STATE UNIVERSITY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Original Assignee Sam Houston State University Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Kovacs Current Assignee (The listed assignees may be inaccurate. ( en Inventor Ilona Petrikovics Kristof I. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Active Application number US14/685,014 Other versions US20150297535A1 Google Patents Formulations of dimethyl trisulfide for use as a cyanide antidoteÄownload PDF Info Publication number US9456996B2 US9456996B2 US14/685,014 US201514685014A US9456996B2 US 9456996 B2 US9456996 B2 US 9456996B2 US 201514685014 A US201514685014 A US 201514685014A US 9456996 B2 US9456996 B2 US 9456996B2 Authority US United States Prior art keywords dmts water solvent system pharmaceutical composition cyanide Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents US9456996B2 - Formulations of dimethyl trisulfide for use as a cyanide antidote US9456996B2 - Formulations of dimethyl trisulfide for use as a cyanide antidote
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